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The National Cancer Institute tested TiO2 for possible carcinogenicity by the oral route of exposure by feeding rats and mice with TiO2 (size not specified) at doses 25,000 or 50,000 ppm TiO2 for 103 weeks. They concluded that TiO2 was not carcinogenic.Also, the study with rats fed diets containing up to 5 % TiO2 coated mica for 130 weeks showed no treatment-related carcinogenicity. Since the size and other TiO2 properties were not specified or determined, we cannot generalize this conclusion and we have to take into account other possible outcomes of this scenario in different exposure conditions (other size/crystalline structure of TiO2 etc.).

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One of the key areas of focus for TiO2 technology manufacturers is environmental sustainability. With increasing concerns about climate change and environmental impact, TiO2 manufacturers are exploring ways to reduce their carbon footprint and minimize waste in their production processes. By implementing new technologies, such as recycling and waste reduction initiatives, TiO2 manufacturers are able to produce TiO2 products in a more eco-friendly manner.

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